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Laboratoire de Photonique, Numérique et Nanosciences (LP2N)
Post-doctoral positions: Imaging the fate of stem cell- derived organoids and tumor spheroids confined in hydrogel capsules formed by microfluidics
Laboratoire de Photonique, Numérique et Nanosciences (LP2N)
LP2N is a Joined Research Unit (JRU 5298) between Institut d’Optique Graduate School (IOGS), University of Bordeaux and CNRS.
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Publié: il y a 10 mois
Date limite d'inscription: Non Spécifiée
Localisation: Talence, France
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Post-doctoral positions: Imaging the fate of stem cell- derived organoids and tumor spheroids confined in hydrogel capsules formed by microfluidics

Location: Bordeaux
Laboratory : Laboratoire de Photonique, Numérique et Nanosciences (LP2N) – BiOf team (http://biof-lab.org/)
Contact : pierre.nassoy@u-bordeaux.fr and gaelle.recher@institutoptique.fr
Starting date : June-September 2018
Salary: full-time yearly gross salary ~ 55 000 € depending on experience
Duration: 12 months with possible renewal up to 36 months
Fields and key words: Biophotonics, Stem cell Biology, Biophysics, Advanced 3D optical imaging, Oncophysics, Optofluidics, Developmental Biology,  Microfluidics.

Context of the project:

The BiOf lab has recently developed a platform to produce multicellular spheroids and organoids in a controlled and high throughput manner. Tumor spheroids are aggregates of cancer and stromal cells that mimic the behavior and growth of micro-tumors. Organoids are formed may be derived from stem cells and used for tissue engineering, regenerative medicine or cell therapy. The microfluidic technology is inspired from a culinary creation, the Flavor Pearls. It is based on the use of a co-extrusion device and allows us to encapsulate cells and subsequently culture spheroids/organoids. An extension of the method leads to the formation of cell monolayers that are closed on themselves in a spherical (cyst) or cylindrical (vessel) geometry. We wish to exploit these technological advances for engineering healthy or pathological tissues and to perform a comprehensive biophysical/biomechanical investigation of the fundamental growth and homeostasis mechanisms that regulate tissue and organ development.

Missions and profiles:

Two post-doc positions are available. We seek for two talented scientists with, for the first one, a background in biophotonics/microfluidics/optofluidics and interest for biological/medical applications (with basic expertise in cell biology), and for the second one, a background in cell/developmental biology and motivation for developing physical approaches (with basic expertise in bio-imaging and image analysis). Both postdocs will be involved in the multidisciplinary projects developed in the lab and based on the Cellular Capsules Technology. In particular, they will explore the impact of mechanical stress on the fate of induced pluripotent stem cells, precursor cells or cancer cells cultured in a three-dimensional confining environment. In either case, experiences in cell culture and bio-imaging are mandatory.  Expertise in stem cell biology or advanced microscopy (holographic, confocal, …) will be appreciated. 

How to apply?

Applicants should email curriculum vitae, statement of research interests and letters from  two-three references to Pierre Nassoy (pierre.nassoy@u-bordeaux.fr) and Gaëlle Recher (gaelle.recher@institutoptique.fr).

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