Université Bretagne Loire
Postdoctoral position: A study of the anti-edema effect of CDK inhibitors after focal cerebral ischemia in rat
Université Bretagne Loire
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Publié: il y a 7 jours
Date limite d'inscription: févr. 15
Localisation: RENNES CEDEX, France
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Postdoctoral position: A study of the anti-edema effect of CDK inhibitors after focal cerebral ischemia in rat

Research Fields: Stroke, neuroprotection, cerebral edema, Cyclin dependant kinase, Blood brain barrier
Work Place: Brest (Brittany, France)
Research Laboratory: Inserm 1078
UBL Research Department: Head(s) of the Scientific Project: Pr. S. Timsit
Offer type: postdoctoral researcher (short term contract, 12 months,
possibly once renewable)
Hiring Institution: UBL
Application deadline:  15th February  2018
Job Starting Date: 1st March  2018

Environment

The aim of the laboratory is to decipher the relationship between the structure of the genes and their function and between genotype and phenotype, from gene to patient. To carry out these projects, Unit 1078 relies on genetics and molecular genomics approaches, genetic epidemiological data, expertise in transcription, splicing and the development of original research models such as the baker's yeast. The expected results are: an increasing knowledge concerning the molecular basis of the gene of interest and also the development of new diagnostic and therapeutical strategies in some model diseases.

The stroke team is composed of a PhD student, a post-doc skilled in stroke experimental models lead by a senior scientist (S.T). This team is embedded in the larger research group of Emmanuel Genin on functional genetics with wide competence from molecular biology, biochemistry, genetic epidemiology. ST is a Professor of Neurology specialized in stroke and develops since many years research on neuroprotection (see references). He is at the head of the Neurology Department at the CHRU of Brest. His team collaborates with molecular biologists, geneticans and bioinformaticians. The aim of this translational team is focused on ischemic stroke to develop therapeutic drugs in ischemic stroke. Patents have already been filed patents in the field.

Mission (scientific project)

Stroke represents the third cause of death in industrialized countries and the second cause in the world according to the world health organization (WHO). Cerebral edema increases intra-cranial-pressure and is the main cause of death after a stroke at the acute phase. There is no medical therapeutic treatment of cerebral edema. The only proposed treatment is neurosurgical, hemicraniectomy. Our previous work showed that a CDK (Cyclin Dependant Kinase) inhibitor was able to decrease brain edema of 37% after focal stroke ischemia compared to controls. The main objective of this project is to study the effect of a CDK inhibitor on cerebral edema in a rat cerebral focal ischemia model. Our previous work clearly showed that a CDK inhibitor had a pleiotropic benefic effect including a decrease of brain edema, neuroprotective properties by decreasing the size of the infarction, and an improvement of motor deficit. This new project will allow better understanding of the effect of CDK inhibitors on brain edema and may contribute to the development of a new therapeutic strategy in stroke. A patent on the use of a CDK inhibitor on stroke has been already delivered. Further study on CDK inhibitor and brain edema in stroke will allow to better understand the mechanism of brain edema decrease and finally to propose new therapeutic strategies for the treatment of brain edema which represents the major cause of acute death after stroke.

Required Profile

Doctor (PhD) in Life Sciences preferentially in Neurosciences, with experience in experimental animal’s models preferentially in models of ischemic stroke with a maximum 3 years of experience after thesis defense[1]. Experience in tissue analysis (histological staining, immuno-histochemistry), cellular and molecular biology (FACS, RT-PCR) is required.

Usefull References

  • Rousselet E.,Létondor A. , Menn B., Courbebaisse Y., Quillé M.L., Timsit S. Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study. JCBFM 2017
  • Timsit S., Menn B. Cyclin-dependent kinase inhibition with roscovitine: neuroprotection in acute ischemic stroke. Clin. Pharmacol. Ther. 2012; 91: 327-332.
  • Menn B, Bach S, Blevins TL, Campbell M, Meijer L, Timsit S. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 ;5 : e12117.
  • S. Timsit and B. Menn. Cerebral ischemia, cell cycle elements and Cdk5. Biotechnol. J. 2007, 2, 958–966
  • S. Timsit Stroke at the beginning of the XXIst century. Presse Med. 2016; 45:e389-e390.
  • S Timsit, P Bailly, E Nowak, FM Merrien, D Herve, I Viakhireva-Dovganyuk, A Jourdain, E Thomas, P Goas and F Rouhart. Cryptogenic mechanism in ischaemic stroke patients is a predictor of 5-year survival: A population-based study. European Stroke Journal 2016, 1:279-287.

How to apply ?

Please send the following documents by email to: serge.timsit@chu-brest.fr with copy to recherche@u-bretagneloire.fr:

  • Short Curriculum Vitae and a covering letter showing your interest and especially addressing your professionnel project
  • A list of your major works (2 pages max.) : scientific publications, patents and others scientific productions
  • Letters of recommendation (not required)
  • A copy of your PhD diploma[2]

The general selection process is described here:

https://u-bretagneloire.fr/dossiers/postdoc/candidatures

The period of audition last until February 15th 2018. A jury composed of at least 3 members, including the Director of the Laboratory and the Head of the scientific project, will audition the candidates either in Brest or by visioconference if necessary.

Annual Gross Salary: 50 000 euros (to be confirmed)

This Fellowship is cofunded by Université Bretagne Loire and another support.

The Université Bretagne Loire federates 7 universities, 15 “grandes écoles” and 5 research organiations in the West of France (Bretagne and Pays de la Loire). This community of universities and institutions aims to develop the scientific and academic potential of this territory at national and international level.

 

[1] The thesis defense must have taken place after 31/08/2014, except in rare exceptions. Periods of sickness, maternity or parental leave shall not be counted in this 3 years period.

[2] For doctors graduated from a French establishment, a link to the thesis notice in the SUDOC Catalogue or the French official portal Theses.fr is sufficient.

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