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Temporary Employment 1 Year with option of extension
Your Responsibilities
Conducting and writing a dissertation at the University of Graz under the supervision of Univ. Prof. Frank Madeo and Co-Supervision of Dr. Andreas Zimmermann
Conducting experiments and data analysis
Independent planning and evaluation of scientific experiments
Presenting and discussing data in regular internal and external meetings as well as at (inter)national conferences
Publishing in internationally renowned, peer-reviewed journals
Co-supervising students at the Bachelor's or Master's level
Opportunity to conduct part of the project in a host laboratory abroad
Your Profile
Completed diploma or master’s degree in the area of life sciences or natural sciences
Eligible as a graduate student at the University of Graz, Austria
Theoretical and practical knowledge in biochemistry, molecular and cell biology
Ideally, practical knowledge of working with mouse models
High level of commitment, personal initiative, and self-motivation for scientific work
Excellent knowledge of written and spoken English
High degree of personal responsibility and ability to cooperate
Excellent social skills and ability to work in a team
The following documents are required for a complete application:
Motivation letter, including a ranking if multiple PhD projects are of interest
Academic CV including Abstract of your master thesis
Proof of completion of the required degree as stated in the job posting
Two recommendation letters, which must be sent directly by the refeeres to [email protected] until the application deadline
Hearing 23rd June 2025 in Graz
Project description
Background:
High-calorie, obesogenic diets are strongly associated to accelerated aging and foster the emergence of typical aging-associated disease like metabolic syndrome and cardiovascular complications. Data from animal studies suggest that disturbed polyamine homeostasis, specifically insufficient polyamine supply in specific tissues, could be causally involved in the negative effects of obesogenic diets. Polyamines are essential for cell-autonomous function, e.g., autophagy, as well as non-autonomous processes, e.g., (sterile) inflammation. Yet, despite these critical roles of polyamines, the molecular etiology of polyamine disbalance under high-calorie diets is insufficiently understood.
Hypothesis and Objectives:
We hypothesize that insufficient spermidine supply and/or maladaptive changes in polyamine metabolism is a causal driver for accelerated aging under high-calorie, obesogenic diets and that spermidine supplementation may ameliorate these effects. Through time-resolved molecular fingerprinting of relevant animal tissues, we will pin down the impact of high-calorie diets on polyamine homeostasis. These results will be complemented by clinical biopsies to evaluate the translational potential of the findings. Importantly, diversity of gut microbiota, an important source of bioavailable polyamines, will be closely monitored.
Methodology:
As part of the MetAGE Cluster of Excellence, you will work hands-on with rodents and investigate transcriptomic, proteomic and metabolomic changes of various tissues, supported by an in-house data science platform. Microbiome analyses will be conducted in close collaboration with the Medical University of Graz. The MetAGE consortium will provide access to human samples, allowing the translation of preclinical findings into human aging research.
We offer an annual gross salary of € 52,007.20 for a fulltime position.
We Offer
Meaning: We offer meaningful work for the world of tomorrow.
Our internal continuing education program is as colorful as the university itself.
Collaboration: With us, you'll find interdisciplinary, cross-professional opportunities to work together.
Benefits: Of course, there are all the usual benefits, from A "access to healthcare services" to Z "Zero emission goal".
Diversity: Besides our various scientific fields and their related issues, we offer a working environment in which diversity is lived.
Flexibility: We demonstrate flexibility not only with the various working time models but also through the offers for the compatibility of family and career.
About us
At the University of Graz, 4700 employees work together on future questions and solutions for the world of tomorrow. Our students and researchers take on the major challenges of society and share their knowledge. We work for tomorrow. Be part of it!
The University of Graz strives to increase the proportion of women in particular in management and faculty positions and therefore encourages qualified women to apply. In the event of underrepresentation, women with equal qualifications are generally given priority for admission. We welcome applications from persons with disabilities who meet the requirements of the advertised position.
Please note that in order to comply with the applicable data protection regulations, we can only accept applications via our web-based applicant tool for this vacant position.
Choosing the right university can be a challenging decision in a researcher's career. At the University of Graz, this choice is made easier by a unique combi...
