Do you want to contribute to top quality medical research?
In our research group, you will find a unique opportunity to work closely with top researchers at the interface of vascular biology and neuroscience to jointly understand how the human brain becomes vulnerable during injury, neurodegeneration and aging. Our recent work (Månberg et al. Nature Medicine 2021) showed that vascular and glial cells contribute to dynamics of neurodegeneration and this project will aim to refine our understanding of cellular mechanisms, biomarkers and genetic risk of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and scarring in the central nervous system. We offer an engaging and international research environment where you will have the opportunity to contribute to high quality research at the top international level.
Division
The successful candidate will work in the Applied Immunology & Immunotherapy group with dr. Sebastian Lewandowski – a team leader in Vascular Neurology. The team is part of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) division which gathers around 40 researchers working on different aspects of the pathogenesis of Multiple Sclerosis (MS) and other neurodegenerative diseases, including genetics, epidemiology, immunology and epigenetics, with excellent clinical cohorts and experimental models. The Applied Immunology & Immunotherapy group is physically located at the Center for Molecular Medicine, a translational medical center with ~500 researchers working on complex diseases, and with extensive national and international collaborations. The Applied Immunology & Immunotherapy group studies why chronic neurodegenerative diseases occur, and then devise ways to prevent or treat them, applying a range of molecular immunological techniques, experimental models and patient cohorts.
Duties
The project combines single-cell, multi-omics data with large scale human genetics to investigate the cellular origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with particular focus on the role of blood vessels. The postdoctoral candidate will work closely with researchers in the team as well as with our collaborators and be responsible for data analysis, visualization, and development of new computational methods for processing and analysis of large-scale omics data.
We welcome applications from candidates with pure computational background and those combining experimental and theoretical approaches.
Requirements:
- Well-documented expertise in any of the following areas: next-generation sequencing data analysis (singe cell and spatial sequencing).
- PhD in Computer science, Biostatistics, Bioinformatics, Neuroscience, or similar field.
- Proficiency in written and spoken English.
- Previous work with large-scale data analysis, integration and visualization.
- Proficiency in scripting language (Python or R) database development, maintaining & sharing code repositories.
- Curiosity to solve fundamental biological questions and enthusiasm to lead new independent projects.
- Ability to formalize a biological question into a computational model.
Merits:
- Computational genomics, medical statistics, computational biology and/or imaging analysis.
- Experience with NGS (10x platform, Smart-Seq) or other high-throughput/dimensionality methods.
- Comparative biology of mammalian nervous system across species.
Entry requirements
Postdoctoral scholarships may be established for foreign researchers who pursue their postdoctoral research in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the postdoctoral education.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.
Location: Solna
Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
Application process
An application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
Read more about the Department of Clinical Neuroscience
Read more about working at Karolinska Institutet
The application is to be submitted on the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for all!
First day of employment: According to agreement
Salary: Scholarship paid out on 6 months basis
Reference number: STÖD 2-1691/2025
Contact: - Mikaela Hernberg, HR Administrator, +46852483047,[email protected]
- Sebastian Lewandowski, Team leader, [email protected]
Union representative: - Bodil Moberg, ST-OFR, 08-52483601
- Henry Wölling, SEKO, [email protected]
- Arsalan Amir, SACO, 070-4831165
Published: 2025-04-22
Last application date: 2025-05-22
