PhD Thesis Student (f/m) on ID30A in the Structural Biology group

The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.

Thesis subject: Exotoxin A from Pseudomonas aeruginosa at MASSIF-1: fragment screening in the era of Artificial Intelligence Pseudomonas aeruginosa is human pathogen which has been classified by the World Health Organisation as one of the three highest priority antibiotic-resistant bacterias. It is one of the leading causes of hospital-acquired-infections and was responsible for more than half a million deaths in 2019. Central to its virulence exotoxin A protein, which inactivates the host cell translational machinery leading to cell death. In this Ph.D., the successful candidate will identify compounds that modulate the activity of this enzyme using a combination of AI based virtual screening, activity assays, and high throughput x-ray crystallography on the ESRF MX beamlines. 

- Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biophysics, biology or physics

- Background in structural biology is desirable

- Ability to interact within a multi-disciplinary team

- Proficiency in English (working language at the ESRF) 

The salary will be calculated on the basis of relevant qualifications and professional experience.

Do you recognize yourself in this description? Apply now for your next professional adventure!

What we offer:

- Join an innovative international research institute, with a workforce from 38 different countries

- Collaborate with global experts to advance science and address societal challenges

- Come and live in a vibrant city, in the heart of the Alps, and Europe's Green Capital 2022

- Enjoy a workplace designed to support your quality of life

- Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble For further information on employment terms and conditions, please refer to https://www.esrf.fr/home/Jobs/what-we-offer.html

The ESRF is an equal opportunity employer and encourages applications from disabled persons.