A funded postdoctoral position is available from June 2019 at the VAlMiS (Vin Aliment Microbiologie Stress) Unit, UMR PAM, Dijon (Scientific leader of the project: Pr. Frederic Dalle). This one-year position is part of a collaborative ANR project ‘Lipidic Purge’ involving the VAlMiS unit and the UPR 9022 CNRS Strasbourg (Dr. Ferrandon Dominique). The present project follows up a previous ANR grant (BEELOSS) in which the UPR 9022 made the major discovery that pesticide exposure favors intracellular parasitism by microsporidia and kills insects (Drosophila model) due to lipidic purge in enterocytes as a result of a competition for lipids between the parasitic microorganism and pesticides.
Based on preliminary data reporting lipidic purge in mammalian enterocytes exposed to pesticides, the post-doctoral fellow will study to which extent lipidic-purge is conserved in mammals. The project will specify the cellular and molecular mechanisms of this enterocytic purge in mammalian in vitro models. It will also investigate the detrimental interaction possibly existing between pesticide exposure and (i) the composition of the gut microbiota, (ii) the mechanisms of interaction of microorganism models (including Candida albicans) with the gut mucosa.
This project will be conducted in the « Pathophysiology of systemic infections » team of the VAlMiS Unit, UMR PAM, Dijon, France. This unit has expertise in host-pathogen interaction of microorganisms with gastro-intestinal mucosa. The University of Burgundy campus hosts expert teams in immunology, microbial pathogenesis, as well as cutting-edge technical platforms.
We are looking for a highly motivated investigator with a PhD in host pathogen interactions and/or cellular and molecular biology/immunology of intestinal cells, a taste for multidisciplinary studies and an ability to work within a team. A solid expertise in cellular biology of the intestinal cells is expected. Experience in animal models and in microbiology will be appreciated.
The post-doctoral position is for 1 year, renewable.
Starting date: September 2019
Interested candidates should send a letter summarizing research interests and career goals, CV with publication list and contact informations from two academic references to: Pr. Frederic Dalle (E-mail: firstname.lastname@example.org)Apprenez-en davantage
|Intitulé||One-year post-doctoral position in host-pathogen interactions at University of Dijon|
|Employer||Université Bourgogne Franche-Comté (UBFC)|
|Job location||32, avenue de l’observatoire, 25000 BESANCON|
|Publié||juillet 16, 2019|
|Date limite d'inscription||Non Spécifiée|
|Types d'emploi||Post doc  |
|Domaines de recherche :||Pathologie,   Biologie moléculaire,   Microbiologie,   Immunologie,   Biologie cellulaire,   Maladies infectieuses  |