Université Grenoble Alpes

Post-Doctoral Position «Spatio-temporal dynamics of microvascular networks»

2022-10-31
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Characteristics of the position:

Functions/ features Young researcher – Post-Doctoral position 

Employment type (referens III ) BAP C Sciences de l'Ingénieur et instrumentation scientifique Ingénieur Recherche C1B42

Category

Body 1.2 Young researcher 

Quotas 100%

Assignment: 

The successful candidate will be affiliated to the Rheology and Processes Laboratory (LRP) and will also work at the Interdisciplinary Physics Laboratory (LIPhy) in Grenoble.

Context and work environment 

Structure description

The partner laboratories (LPR and LIPhy) are part of the LabEx Tec 21, which is financing this project.

The Rheology and Processes Laboratory (UMR5520 CNRS, Grenoble INP and UGA) has a staff of about 50 people and carries out research activities in two main disciplines: "complex fluid mechanics", with a focus on multiphase fluids and microfluidic approaches, and "process engineering". Within the team ''Rheology, Processes and their Intensification'' (RhePI), the laboratory conducts research on complex fluids, materials, processes and their intensification, using multi-scale methods and multi-physics couplings. Model materials, materials formulated for industry or biological fluids, polymers, suspensions, colloids, gels or self-assembling systems whose behaviour under deformation is studied are present in all fields of industry, health, energy and the environment.

The Interdisciplinary Physics Laboratory (UMR5588 CNRS and UGA) has a staff of about 200 people. Physics is seen at LIPhy as a general method of approaching complex phenomena in various disciplines. Within it, the team Mechanics of Cells in Complex Environments (MC2) carries out interdisciplinary research based on mechanical and physical approaches to the dynamics of living or biomimetic systems and materials (biological fluids, cells and capsules, tissues). Experimental, theoretical and numerical skills allow us to address different biological and bioinspired systems that have complex physical interactions at different scales in common

Laboratory sites: www.laboratoire-rheologie-et-procedes.fr and https://www-liphy.univ-grenoble-alpes.fr and www.tec21.fr

Team description (N+1 and colleagues) :  under the authority of …. Team composed of X agents (X A, X B, X C…)

The research will take place at LIPhy and LRP on the same campus, under the supervision of Gwennou Coupier (CNRS Research Fellow, LIPhy) and Thomas Podgorski (CNRS Research Director, LRP). The design and fabrication of the microfluidic chips will be done in interaction with the technical team of the microfabrication department at LIPhy.

Position’s mission and main activities  

In the microcirculation, blood flows through a complex network of capillaries where the coupling between local rheology and phase separation at bifurcations leads to strong heterogeneities in red blood cell distribution. Theoretical predictions by project collaborators (N. Karst, J. Geddes, Boston, USA) supported by preliminary experiments reveal the possibility of multiple solutions and oscillating states of the globule distribution and flow velocities in the different branches, even for relatively simple and symmetric networks. The project consists of a systematic experimental study of the spatial distribution of flows of red blood cell suspensions in model microchannel networks, involving local velocity and concentration measurements. It aims to establish the conditions under which flow instabilities lead to multiple solutions or oscillating regimes. The project has a duration of 12 months from the date of recruitment expected in November or December 2022.

Mission:

The person recruited will be in charge of the implementation of the experimental part of the research project on blood flow dynamics in model microcirculatory networks. He/she will design, fabricate and implement the microfluidic systems in interaction with the project PIs and laboratory technicians, and perform the experiments and data analysis. 

Carefully designed microfluidic systems will enable a systematic experimental study of the flow of red blood cell suspensions in simple, symmetrical arrays, which have been shown to be subject to multistability and symmetry breaking. The project aims to explore the conditions leading to these symmetry breaks, multiple flow configurations or oscillatory states, in particular by controlled perturbations of the system via adapted microfluidic devices to assess the stability of the solutions and to induce transitions between metastable states of the system. In addition, the impact of red blood cell aggregation on these phenomena will receive particular attention.

Main activities:

List here the activities in the order of importance or quota 

Design, manufacture and implementation of microfluidic circuits dedicated to the study (15%)

Conduct of experiments (preparation of samples provided by the Etablissement Français du Sang, control of microfluidic flows, microscopy image acquisition) (30%)

Data analysis (image processing for velocimetry and local red cell concentration measurements) (30%)

Comparison/interaction with theoretical approaches (15%)

Writing and communication of results (articles, conferences) (10%)

Event - Objective result(s) setting the end of the agent's mission: 

The realization of experiments will lead to the establishment of stability diagrams of flow configurations in model microcirculatory networks, as a function of control parameters such as hematocrit, imposed velocities or pressure differentials and rheological properties of suspensions (in particular their degree of aggregation). These results will lead to the writing of articles in collaboration with the theoretical partners and to communications in conferences.

Evaluation and monitoring of the achievement of the result(s) : 

The post-doc will be in constant interaction with the direct supervisors and weekly meetings will allow to evaluate and guide the work. There will also be regular video-conference discussions and meetings with the theoretical collaborators. 

Restriction or constraints related to the position  

The two partner laboratories (LRP and LIPhy) have expertise in the performance of experiments on biological fluid dynamics and have the necessary equipment for the preparation of samples and the implementation of experiments (microscopy, flow control etc.). LIPhy's microfabrication platform allows the rapid production of dedicated microfluidic chips. 

Both structures are subject to the usual daytime working hours of the UGA laboratories. The candidate will be required to travel frequently (1-2 times/week) to the Grenoble Alpes University Hospital site to collect blood samples from the EFS, and may be required to travel to national or international conferences.

Desired profile

Expected skills (priority) :

  • Trade skills/ expertise

Candidates will have a PhD with strong experience in microfluidics, including microfluidic chip design and fabrication as well as flow control and microscopy. He/she will be required to develop data analysis routines and experience in image processing is appreciated. Additional skills in fluid dynamics, rheology and non-linear physics are welcome.

  • Personal skills

The candidate should have a good level of spoken, read and written English (B2 minimum). 

A good ability to interact in a team is desirable, as well as an open mind and good communication skills.

Supervisory mission: ☐ Yes ☒ No

Desired professional experience : ☒ beginner  ☒ 2 to 5 years 

Previous formation, diplomas

Candidates will have a PhD with strong experience in microfluidics, including design and fabrication of microfluidic chips as well as flow control and microscopy.

General information

The gross salary will be 2656 euros/months, equivalent to a net salary of 2134 euros/month.

Contact for the questions related to the position: 

Interested candidates should send their CV and cover letter to :

Thomas PODGORSKI, Resarch Director at LRP :

thomas.podgorski@univ-grenoble-alpes.fr 

and

Gwennou COUPIER, Research associate at LIPhy :

gwennou.coupier@univ-grenoble-alpes.fr

Deadline for the application: 31st October 2022

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Détails de l'offre

Titre
Post-Doctoral Position «Spatio-temporal dynamics of microvascular networks»
Localisation
621 avenue Centrale Grenoble, France
Publié
2022-06-08
Date limite d'inscription
2022-10-31
Type de poste
Enregistrer en tant que favori

A propos de l'employeur

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