Votre alerte-emploi vient d’être créée avec succès.
Université Bretagne Loire
Postdoctoral Fellow - A study of the anti-edema effect of CDK inhibitors after focal cerebral ischemia in rat
Université Bretagne Loire
Université Bretagne Loire is a regional network with an international outlook
Visitez la page de l'employeur
DÉTAILS DE L'OFFRE
Publié: il y a 21 jours
Date limite d'inscription: sept. 30
Localisation: RENNES CEDEX, France
Veuillez mentionner que vous avez trouvé ce poste sur Academic Positions lors de votre candidature.
PARTAGER CE POSTE

Postdoctoral Fellow - A study of the anti-edema effect of CDK inhibitors after focal cerebral ischemia in rat

Project Title: A study of the anti-edema effect of CDK inhibitors after focal cerebral ischemia in rat

Research Fields: Stroke, neuroprotection, cerebral edema, Cyclin dependant kinase, Blood brain barrier

Work Place: Brest (Brittany, France)

Research Laboratory: Inserm 1078

UBL Research Department:

Head(s) of the Scientific Project: Pr. S. Timsit

Offer type: postdoctoral researcher (short-term contract, 12 months, possibly once renewable)

Hiring Institution: UBL

Application deadline: 30th September 2018

Job Starting Date: 1st October 2018 - 1st January 2019

Environment

The aim of the laboratory is to decipher the relationship between the structure of the genes and their function and between genotype and phenotype, from gene to patient. To carry out these projects, Unit 1078 relies on genetics and molecular genomics approaches, genetic epidemiological data, expertise in transcription, splicing and the development of original research models such as the baker's yeast. The expected results are: an increasing knowledge concerning the molecular basis of the gene of interest and also the development of new diagnostic and therapeutical strategies in some model diseases.

The stroke team is composed of a PhD student, a post-doc skilled in stroke experimental models lead by a senior scientist (S.T). This team is embedded in the larger research group of Emmanuel Genin on functional genetics with wide competence from molecular biology, biochemistry, genetic epidemiology. ST is a Professor of Neurology specialized in stroke and develops since many years research on neuroprotection (see references). He is at the head of the Neurology Department at the CHRU of Brest. His team collaborates with molecular biologists, geneticans and bioinformaticians. The aim of this translational team is focused on ischemic stroke to develop therapeutic drugs in ischemic stroke. Patents have already been filed patents in the field.

Mission (scientific project)

Stroke represents the third cause of death in industrialized countries and the second cause in the world according to the world health organization (WHO). Cerebral edema increases intra-cranial-pressure and is the main cause of death after a stroke at the acute phase. There is no medical therapeutic treatment of cerebral edema. The only proposed treatment is neurosurgical, hemicraniectomy. Our previous work showed that a CDK (Cyclin Dependant Kinase) inhibitor was able to decrease brain edema of 37% after focal stroke ischemia compared to controls. The main objective of this project is to study the effect of a CDK inhibitor on cerebral edema in a rat cerebral focal ischemia model. Our previous work clearly showed that a CDK inhibitor had a pleiotropic benefic effect including a decrease of brain edema, neuroprotective properties by decreasing the size of the infarction, and an improvement of motor deficit. This new project will allow better understanding of the effect of CDK inhibitors on brain edema and may contribute to the development of a new therapeutic strategy in stroke. A patent on the use of a CDK inhibitor on stroke has been already delivered. Further study on CDK inhibitor and brain edema in stroke will allow to better understand the mechanism of brain edema decrease and finally to propose new therapeutic strategies for the treatment of brain edema which represents the major cause of acute death after stroke.

Required Profile

Doctor (PhD) in Life Sciences preferentially in Neurosciences, with experience on cell culture with a maximum 3 years of experience after thesis defense (1). Experience in tissue analysis (histological staining, immuno-histochemistry), cellular and molecular biology (FACS, RT-PCR) is required.

Usefull References

  • Rousselet E.,Létondor A. , Menn B., Courbebaisse Y., Quillé M.L., Timsit S. Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study. JCBFM 2017
  • Timsit S., Menn B. Cyclin-dependent kinase inhibition with roscovitine: neuroprotection in acute ischemic stroke. Clin. Pharmacol. Ther. 2012; 91: 327-332.
  • Menn B, Bach S, Blevins TL, Campbell M, Meijer L, Timsit S. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 ;5 : e12117.
  • S. Timsit and B. Menn. Cerebral ischemia, cell cycle elements and Cdk5. Biotechnol. J. 2007, 2, 958–966
  • S. Timsit Stroke at the beginning of the XXIst century. Presse Med. 2016; 45:e389-e390.
  • S Timsit, P Bailly, E Nowak, FM Merrien, D Herve, I Viakhireva-Dovganyuk, A Jourdain, E Thomas, P Goas and F Rouhart. Cryptogenic mechanism in ischaemic stroke patients is a predictor of 5-year survival: A population-based study. European Stroke Journal 2016, 1:279-287.

How to apply?

Please send the following documents by email to: serge.timsit@chu-brest.fr with copy to recherche@u-bretagneloire.fr:

  • Short Curriculum Vitae and a covering letter showing your interest and especially addressing your professionnel project
  • A list of your major works (2 pages max.) : scientific publications, patents and others scientific productions
  • Letters of recommendation (not required)
  • A copy of your PhD diploma (2)

The general selection process is described here:

https://u-bretagneloire.fr/dossiers/postdoc/candidatures

The period of audition last until September  30th 2018. A jury composed of at least 3 members, including the Director of the Laboratory and the Head of the scientific project, will audition the candidates either in Brest or by visioconference if necessary.

Annual Gross Salary: 50 000 euros (to be confirmed)

This Fellowship is cofunded by Université Bretagne Loire and another support.

The Université Bretagne Loire federates 7 universities, 15 “grandes écoles” and 5 research organiations in the West of France (Bretagne and Pays de la Loire). This community of universities and institutions aims to develop the scientific and academic potential of this territory at national and international level.

(1) The thesis defense must have taken place after 31/08/2014, except in rare exceptions. Periods of sickness, maternity or parental leave shall not be counted in this 3 years period.

 

(2) For doctors graduated from a French establishment, a link to the thesis notice in the SUDOC Catalogue or the French official portal Theses.fr is sufficient.

Lire la suite
Candidatez ici

POSTULER

Détails personnels
Upload your CV and attachments
Le format de fichier doit être .doc, .pdf, ou .rtf et le fichier ne peut pas dépasser 2 Mo au total.
Le format de fichier doit être .doc, .pdf, ou .rtf et le fichier ne peut pas dépasser 2 Mo au total.

En déposant une candidature pour un poste publié sur Academic Positions, vous acceptez nos conditions générales et notre politique de confidentialité.

S'ABONNER A DES ANNONCES COMME CELLES-CI

OFFRES D'EMPLOI SIMILAIRES (27)

Aix-Marseille Université
Aix-Marseille Université
Localisation: Marseille , France
Postdoctoral Fellow - AAV Expert
We are looking for a highly motivated Ph.D. with substantial AAV expertise. Our targeted gene therapy team at Aix-Marseille University is developing cutting-edge strategies to treat mouse models of Rett syndrome. Rett syndrome is a severe neurological disorder caused by...
LabEx DISTALZ
LabEx DISTALZ
Localisation: LILLE, France
Post Doc - Study the role of neuronal genomic instability in the pathogenesis of AD and related primary Tauopathies
Job description A 2-year international joint post-doctoral position (two years) is available in the labs of Marie-Christine Galas (Inserm UMR-S1172, Lille, France) and Bart Dermaut (Center for Medical Genetics, Ghent University, Belgium). The general objective of this...
CEA Tech
CEA Tech
Localisation: Grenoble, France
Post Doc - Développement d’un algorithme de traitement d’images dédié à l’analyse d’acquisitions en microscopie défocalisée de culture cellulaires
PsD-DRT-18-0089 DOMAINE DE RECHERCHE Biotechnologie, biophotonique RÉSUMÉ DU SUJET Au CEA-Leti, nous avons validé une plateforme de vidéo-microscopie sans lentille vidéo en enregistrant des milliers d'heures de cultures cellulaires. Et nous avons...
CEA Tech
CEA Tech
Localisation: Grenoble, France
Post Doc - Development of a cell analysis algorithm for phase microscopy imaging
PsD-DRT-18-0089 RESEARCH FIELD Biotechnology, biophotonics ABSTRACT At CEA-Leti we have validated a video-lens-free microscopy platform by performing thousands of hours of real-time imaging observing varied cell types and culture conditions (e.g.: primary...
A*Midex
A*Midex
Localisation: Marseille Cedex 07, France
Postdoctoral Position - Insights into the pathophysiology of neuromuscular diseases through actin and myelin organization measurements
Duration : 24 months from September 2018 Contacts : Valérie Delague, valerie.delague@univ-amu.fr Marc Bartoli, marc.bartoli@univ-amu.fr Website : https://www.marseille-medical-genetics.org/ Neuromuscular diseases are a broad group of clinically and genetically...

CAREER ADVICE

France has a strong academic tradition and is committed to investing in research and education. Here's what French academics make.

By Academic Positions
Posted Jul 06, 2018 at 08:00am

While a good cover letter makes an explicit connection between how your past experience will help you succeed in the postdoc position, a great cover letter sparks the PI’s interest and ensures they read your CV.

By Academic Positions
Posted Aug 14, 2018 at 08:00am

How many times have you been asked, “What do you research?” only to draw a complete blank or ramble on for minutes? Situations like these are why you need an elevator pitch.

By Academic Positions
Posted Aug 10, 2018 at 08:00am