As a PhD candidate, your aim is to identify core post-transcriptional programmes that impact on gene expression variability and ultimately cellular function. You will work on identifying the physical parameters, as well as circuit architectures (i.e. feedback mechanisms) governing gene expression dynamics in mammalian cells. In the first few months you will familiarise yourself with the field and develop a more detailed project outline. Throughout the project, you will gain extensive proficiency in the most current cell-free biochemistry, single-molecule and live-cell microscopy, and mathematical modelling techniques. You will communicate your findings through research articles during the course of your PhD. In addition to your research activities, you will be part of the educational programme of the Institute of Molecules and Materials, where you will develop various critical soft skills such as ethics, planning, and teaching. You will also develop your own scientific voice, as well as broaden and deepen your knowledge of the field of research by participating in symposia and conferences.
For recent work see: Cell, 2018, 173, 1609: Cell Syst., 2018, 7, 384; Nature Nanotech., 2016, 11, 191.
The research project will be carried out in the Biophysical Chemistry group of the Institute for Molecules and Materials and led by Dr Maike Hansen (see here for more information). IMMs goal is to provide world-leading research and training in the area of functional molecules and materials. You will be working with other PhD candidates from the Biophysical Chemistry group of Dr Hans Heus and Prof. Tom de Greef and the Physical Organic Chemistry group of Prof. Wilhelm Huck. You will be working in a dynamic, highly interdisciplinary environment, with access to state-of-the-art microfluidics labs, confocal microscopy set-ups, and cell-culture facilities. The field of stochastic processes has long been investigated in mathematics and physics. The study of stochastic processes in biology, however, is relatively recent and has really taken off since the emergence of single-cell technologies. It is therefore an exciting time to be working in this innovative, interdisciplinary field that is constantly evolving.
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent and collaboration. You have a part to play!
For more information about this vacancy, please contact:
Dr. Maike Hansen,
Please address your application to Dr. Maike Hansen and submit it, using the application button, no later than 17 November 2019, 23:59 Amsterdam Time Zone.
Your application should include the following attachments:
We drafted this vacancy to find and hire our new colleague ourselves. Recruitment agencies are kindly requested to refrain from responding.Apprenez-en davantage
|Intitulé||PhD Candidate for Single-Cell Gene Expression Dynamics|
|Job location||Comeniuslaan 4, 6525 HP Nijmegen|
|Publié||octobre 16, 2019|
|Date limite d'inscription||novembre 17, 2019|
|Types d'emploi||PhD  |
|Domaines de recherche :||Biochimie,   Biophysique,   Chimie analytique,   Biologie moléculaire,   Génétique,   Biologie cellulaire,   Bioingénierie  |