Recently Pr. Stanley Nattel has become the holder of the Atrial Fibrillation (AF) Chair at the Institute of Rhythmology and Cardiac Modeling (LIRYC) in Bordeaux, France. A postdoctoral position is available in LIRYC (https://www.ihu-liryc.fr/en/) and the Nattel Labs (https://www.icm-mhi.org/en/research/labs/fundamental-laboratories/electropharmacology) at the Montreal Heart Institute/University of Montreal/McGill University, to study pathophysiological mechanisms of AF.
Areas of interest include the metabolic control of ion-channel and excitation-contraction function, mechanisms of ROS production, and energetic homeostasis control in AF. We will perform analysis at integrated levels going from in vivo studies in the sheep to isolated mitochondria. Our main goal is to study the dynamic of remodeling processes during AF, with specific attention to electrophysiological, metabolic and structural remodeling. The principal in vivo model will be a sheep AF model recently developed at LIRYC in which we can follow the evolution of AF in real time by telemetry.
The goals of the work are to obtain improved insights into the molecular mechanisms underlying atrial fibrillation, with a view to identifying novel therapeutic targets of potential clinical interest. In parallel, to the analysis performed in the animal, we have a clinical research program exploiting atrial samples and blood from the coronary sinus of patients obtained at the time of clinical electrophysiology study.
The successful candidate will be working with a multidisciplinary team using methods that range from molecular biology through in vitro cellular models, small and large animal models, in vivo electrophysiology, and work with human blood and tissues. The two laboratories involved will provide training in fundamental cardiac electrophysiology and bioenergetics.
Because of the multidisciplinary nature of the work, there are opportunities for qualified fellows with PhDs and/or MDs and a subset of one or more of the following skills:
Basic knowledge in cardiac electrophysiology.
Highly motivated and keen to learn new techniques in different fields (e.g. electrophysiology, bioenergetics, magnetic resonance imaging, proteomics and metabolomics, cell and mitochondrial isolation)
Cellular calcium imaging and handling, including optical mapping at the tissue level, studies of subcellular calcium handling and homeostasis, calcium-handling determinants, function and expression analysis of calcium-handling proteins/processes.
Extensive knowledge and understanding of metabolic regulation of cellular function and mitochondrial pathophysiology.
While experience in cardiac systems is an advantage for all areas, candidates with experience and interest in ion channel physiology, molecular biology and biochemistry, metabolism/mitochondrial function and/or calcium handling in non-cardiac systems and an interest in applying these areas in the heart will be seriously considered.
Interested applicants should send a CV, brief statement of qualifications and basis for interest in the position, copies of up to 3 relevant publications, and the email addresses of 3 appropriate references to Stanley.email@example.com; firstname.lastname@example.org; email@example.com; (cc to JenniferAnne.Bacchi@icm-mhi.org). Include the words “Post-doc in Atrial Fibrillation LIRYC”) in the subject line of your email.
Expires: October the 5th, 2019
Job location: IHU Liryc, Pessac (near Bordeaux), France, Montreal Nattel lab, Canada
Employer: University of Bordeaux
Contract: Duration of the contract is two years
Start: January 2020
Salary: based on University salary gridApprenez-en davantage
|Intitulé||Postdoctoral Fellowship in Molecular Mechanisms of Atrial Fibrillation-Bordeaux, France and Montreal, Canada|
|Employer||LIRYC - Electrophysiology and Heart Modeling Institute|
|Job location||351 cours de la Libération, 33405 TALENCE|
|Publié||juillet 11, 2019|
|Date limite d'inscription||octobre 5, 2019|
|Types d'emploi||Post doc  |
|Domaines de recherche :||Physiologie,   Sciences cliniques,   Biochimie,   Biologie moléculaire,   Cardiologie,   Biologie cellulaire,   Bioingénierie  |