A funded postdoctoral position is available in the “Nods-like receptors in infection and immunity of Lille” Unit headed by Mathias Chamaillard for studying how the T follicular helper cell commitment is influenced by the oscillatory behavior of the gut microbiota and how circadian activity of the gut microbiome is regulated by CD4 T cells over the course of a day. The Chamaillard's laboratory at the Institut Pasteur de Lille is interested in defining how deregulation of several Nods-like receptors break down in colitis-associated colorectal cancer. Using a variety of techniques and complex genetic models, we have contributed to the field of mucosal immunology by identifying novel dendritic cell subsets and several pathways that underlie inflammation-driven carcinogenesis (Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6, J Clin Invest. 2013 Feb;123(2):700-11 and Mucosal Immunol. 2017 Nov 15. doi: 10.1038/mi.2017.87).
Project Outline: The International Agency for Research on Cancer classified shift work with chronodisruption as an exposure circumstance that poses a carcinogenic risk. The circadian clock is an endogenous time-tracking system that allows most living organisms to anticipate and adapt to several environmental changes. In this context, we seek to obtain a mechanistic understanding on the interplay between the circadian activity of the gut microbiome and CD4 T cells. Thanks to excellent facilities at the Institut Pasteur de Lille and to strong collaborations with the Institute Pasteur of Paris and the inflammation research center from the VIB in Ghent, state-of-the-art technologies are available including those combining imaging and flow cytometry. The scientific outputs of our multidisciplinary approach has a direct clinical perspective that will have a broad impact on the development of chronomodulated drugs as exemplified by the strong of interest of stakeholders and biotech companies on the gut microbiota in oncology. Upon completion of the project, we will look for collaboration with industrial partners involved in microbiota-derived molecule development and next generation probiotics development in order to favor public-private partnership either locally or internationally for transfering our results from bench to bedside through clinical trial.
Candidate requirements: The applicants of any nationality must hold a PhD and/or a MD degree and should be highly motivated and ambitious. The applicants should have a strong background in bone marrow chimera experiments, cell cytometry and cellular imaging with a strong interest on oncology and mucosal immunology. Technical expertise in flow cytometry will be of advantage. Fluent knowledge of English and excellent communication skills are expected. Interested candidates are encouraged to submit a motivation letter describing their background, a CV and two references letters to firstname.lastname@example.org.
Expected employment starting date: 2018-06-01.Lire la suite